BEGIN:VCALENDAR VERSION:2.0 CALSCALE:GREGORIAN PRODID:iCalendar-Ruby BEGIN:VEVENT CATEGORIES:Lectures & Presentations DESCRIPTION:MCB Seminar | I’m Aging\, What’s to Blame? The Role of the Gut Microbiota and Autophagy in Longevity\, April 13\n\nThe Molecular and Cellu lar Biology Seminar series features Ibiagbani Max-Harry discussing "I’m Agi ng\, What’s to Blame? The Role of the Gut Microbiota and Autophagy in Longe vity" on April 13 from 4:35 – 5:55 p.m.\n\nContact Dr. Sarah Wyatt\, MCB di rector\, for Teams information.Max-Harry is a graduate student in Biologica l Sciences at Ohio University and a member of the Molecular and Cellular Bi ology program.\n\nAbstract: The causes of aging and possible interventions to slow down the process have be-come major areas of research in recent yea rs. Activation of the self-eating process\, autophagy\, where damaged cells \, organelles and proteins are gotten rid of through lysosomal engulfment h as been shown to slow down aging in mice (1). The mamma-lian target of Rapa mycin complex (mTORc) is activated in the presence of nutrients and is know n to suppress autophagy by inhibiting ULK1\, a key autophagy inducer. Vario us studies show that nutrient deprivation enhances autophagy and longevity in both mice and flies. Rapamycin is a chemical compound which inhibits mTO Rc1 and has been shown to increase lifespan\, slow down age-related disorde rs such as changes in the gut microbiota in different model organisms. Schi naman et al showed that although administering rapamycin affected the gut m icrobiota of Drosophila\, it also slowed down aging in “germ-free” flies wi th no gut microbiota (2). They further showed that knocking out the autopha gy related gene ATG1 prevented rapamycin mediated longevity. These results reveal that although modified by rapamycin\, the gut microbiota\, unlike au tophagy\, is not required for rapamycin action. Further stud-ies are needed to understand if a relationship exists between autophagy and the gut micro biota composition. DTEND:20210413T215500Z DTSTAMP:20241123T192612Z DTSTART:20210413T203500Z LOCATION: SEQUENCE:0 SUMMARY:MCB Seminar | I’m Aging\, What’s to Blame? The Role of the Gut Micr obiota and Autophagy in Longevity\, April 13 UID:tag:localist.com\,2008:EventInstance_36209790922924 URL:https://calendar.ohio.edu/event/mcb_seminar_ibiagbani_max-harry_on_apri l_13 END:VEVENT END:VCALENDAR