BEGIN:VCALENDAR VERSION:2.0 CALSCALE:GREGORIAN PRODID:iCalendar-Ruby BEGIN:VEVENT CATEGORIES:Lectures & Presentations DESCRIPTION:MCB Seminar | Plants as nanofactories: Plant-derived extracellu lar vesicles as novel nanoparticle drug carriers\, Oct. 4\n\nThe Molecular Cellular Biology Seminar series features Shiyu Yuan discussing "Plants as n anofactories: Plant-derived extracellular vesicles as novel nanoparticle dr ug carriers" on Oct. 4 from 3:30 – 5 p.m. in Porter Hall 104. \n\n \n\nYuan is a doctoral student in the Molecular and Cellular Biology program and th e Biological Sciences Department at Ohio University.\n\n \n\nAbstract: Extr acellular vesicles (EVs)\, including exosomes\, are nanoscale membrane-encl osed particles implicated in intercellular communication to facilitate tran sport of proteins and genetic material1. The natural origin of plant-derive d extracellular vesicles (PEVs) allows their isolation from affordable edib le plants in significant quantities and eliminates possible concerns regard ing toxicity. In addition\, plant vesicles are natural carriers of differen t biomolecules. Compared to mammalian EVs\, the remarkably biocompatible\, biodegradable\, and highly abundant properties of PEVs make them gain more and more attention as promising carries for ectopic cargo delivery. Luiza e t al2 investigated the capacity of delivery of functional proteins by grape fruit-derived extracellular vesicles. They isolated EVs from grapefruit jui ce by differential centrifugation followed by characterization of size\, qu antity\, and morphology. In vitro\, they found that native grapefruit-deriv ed extracellular vesicles (GF-EVs) are highly efficient carriers for the de livery of the exogenous Alexa Fluor 647 labeled bovine serum albumin and he at shock protein 70 (HSP70) into both human peripheral blood mononuclear ce lls and colon cancer cells\, and\, most importantly\, they have confirmed t he functional activity of HSP70 in the colon cancer cell culture upon deliv ery by GF‑EVs. In vivo\, analysis of the biodistribution of GF‑EVs in mice demonstrated a significant uptake of extracellular vesicles by the majority of organs. Their study indicates a high potential of native GF-EVs for the safe delivery of exogenous proteins into mammalian cells and tissues\, whi ch provides a strong basis for further studies and development of plant ves icle delivery systems for the use in novel therapeutics and precision medic ine.\n\n \n\nKey reference: \n\ n1 Nemati\, M. et al. Plant-derived extracellular vesicles: a novel nanomedicine approach with advantages and challenges. Cell Commun Sig nal 20\, 69 (2022). https://doi.org:10.1186/s12964-022-00889-1\n\n2 Garaeva\, L. et al. Delivery of functional exogenous proteins by plan t-derived vesicles to human cells in vitro. Sci Rep 11\, 6489 (2021). https ://doi.org:10.1038/s41598-021-85833-y DTEND:20221004T210000Z DTSTAMP:20241124T023901Z DTSTART:20221004T193000Z GEO:39.324787;-82.103474 LOCATION:Porter Hall\, 104 SEQUENCE:0 SUMMARY:MCB Seminar | Plants as nanofactories: Plant-derived extracellular vesicles as novel nanoparticle drug carriers\, Oct. 4 UID:tag:localist.com\,2008:EventInstance_41174490052607 URL:https://calendar.ohio.edu/event/mcb_seminar_plants_as_nanofactories END:VEVENT END:VCALENDAR