BEGIN:VCALENDAR VERSION:2.0 CALSCALE:GREGORIAN PRODID:iCalendar-Ruby BEGIN:VEVENT CATEGORIES:Lectures & Presentations DESCRIPTION:MCB Seminar | From reductionism to globalism: Whole-cell modeli ng\, Oct. 5\n\nThe Molecular and Cellular Biology Seminar series features S hiyu Yuan on Oct. 5 from 4:35 to 5:55 p.m.\n\nContact Dr. Sarah Wyatt\, MCB director\, for more information. \n\nYuan is a graduate student in Biologi cal Sciences and Molecular Cellular Biology.\n\n \n\nAbstract: Biology has traditionally followed a reductionist approach in which individual componen ts of a living system are studied separately. As next-generation experiment s yield data that is high throughput and complex\, there is an increasing n eed for corresponding computational methods to derive knowledge from the da ta and study how components interact to form complex systems1. Whole-cell m odels that incorporate every known gene function to make predictions about integrated and complex biological phenomena may address this need. The conc ept and application of whole-cell modeling was first demonstrated in the si mple organism Mycoplasma genitalium. The model was able to track all of the molecules and interactions within a life cycle of a bacterium\, offering a detailed look into the behavior and function of the cell. The simulations generated by this highly integrated model also compared favorably with publ ished data sets including metabolic fluxes\, metabolite concentrations\, gr owth rates\, and gene and protein expression2. Since then\, the whole-cell modeling approach has been extended to\, a more complicated organism\, E. c oli\, allowing researchers to tap into the extensive data that have resulte d from decades of research into this model organism3. Whole-cell modeling c an be best used for integrating heterogeneous database\, identifying limits of current knowledge\, predicting multi-network phenotypes\, suggesting fu ture experiments that may lead to new knowledge\, and provide a framework f or the safe and effective design of genetically modified organisms4.\n\n \n \nKey reference:\n\n1 Macklin\, D. N.\, Ruggero\, N. A. & Cove rt\, M. W. The future of whole-cell modeling. Curr Opin Biotechnol 28\, 111 -115\, doi:10.1016/j.copbio.2014.01.012 (2014).\n\n2 Karr\, J. R. et al. A whole-cell computational model predicts phenotype from genotyp e. Cell 150\, 389-401\, doi:10.1016/j.cell.2012.05.044 (2012).\n\n3 Macklin\, D. N. et al. Simultaneous cross-evaluation of heterogeneous E. coli datasets via mechanistic simulation. Science 369\, doi:10.1126/sci ence.aav3751 (2020).\n\n4 Carrera\, J. & Covert\, M. W. Why Bu ild Whole-Cell Models? Trends Cell Biol 25\, 719-722\, doi:10.1016/j.tcb.20 15.09.004 (2015). DTEND:20211005T215500Z DTSTAMP:20241124T104654Z DTSTART:20211005T203500Z LOCATION: SEQUENCE:0 SUMMARY:MCB Seminar | From reductionism to globalism: Whole-cell modeling\, Oct. 5 UID:tag:localist.com\,2008:EventInstance_37775919611000 URL:https://calendar.ohio.edu/event/mcb_seminar_shiyu_yuan_on_oct_5 END:VEVENT END:VCALENDAR