BEGIN:VCALENDAR VERSION:2.0 CALSCALE:GREGORIAN PRODID:iCalendar-Ruby BEGIN:VEVENT CATEGORIES:Lectures & Presentations DESCRIPTION:Biological & Biomedical Seminar | Novel iron-regulating structu res in pancreatic beta-cells\, Nov. 13\n\nThe Biological Sciences & Biomedi cal Sciences Joint Research Seminar Series features presents Dr. Kira Slepc henko\, currently a postdoc with Dr. Daewoo Lee from the Biological Science s Department\, present a seminar entitled “Novel iron-regulating structures in pancreatic beta-cells” on Nov. 13 at 4 p.m. in Irvine 159. \n\n \n\nAb stract: Research The proper regulation of iron is crucial to the function o f all cells\; however iron dysregulation leads to a newly described cell de ath ‐ ferroptosis. We describe a novel iron‐regulating modality found in pa ncreatic beta cells\, which are dense structures that accumulate iron. Sync hrotron X‐ray fluorescence revealed that intracellular iron puncta accumula te iron after exposure of beta cells to low doses of cytokines IL‐6 and IL‐ 1beta. Additionally\, after exposure to iron\, the puncta iron content sign ificantly increases\, suggesting that iron puncta respond to cellular stres s by accumulating iron. Finally\, we show that cytokine exposure increases the overall average iron density of puncta and protects pancreatic beta cel ls from ferroptosis\, suggesting that iron puncta sequester iron and decrea se susceptibility of pancreatic beta cells to factors/stressors that typica lly increase the risk of ferroptotic cell death. DTEND:20231113T220000Z DTSTAMP:20241124T050624Z DTSTART:20231113T210000Z GEO:39.325597;-82.105136 LOCATION:Irvine Hall\, 159 SEQUENCE:0 SUMMARY:Biological & Biomedical Seminar | Kira Slepchenko on Nov. 13 UID:tag:localist.com\,2008:EventInstance_44404600601476 URL:https://calendar.ohio.edu/event/seminar_kira_slepchenko_on_nov_13 END:VEVENT END:VCALENDAR