Department of Biomedical Sciences/Edison Biotechnology Institute, Heritage College of Osteopathic Medicine
Education
Ph.D. Molecular and Cellular Biology/Dec. 2014/Ohio University/Athens, Ohio, USA
M.S. Biochemistry and Molecular Biology/Jun. 2009/Shanghai University/Shanghai, China
B.S. Biological Engineering/Jun. 2006/Shanghai University/Shanghai, China
Research
I conduct cancer research in Dr. John Kopchick’s laboratory to understand the role of growth hormone and its actions on the progression of different types of cancer using cell culture, mouse models, and clinical human cancer data. We are working on elucidating the mechanisms involved in these processes, including drug resistance, and trying to apply growth hormone receptor antagonism as a new therapeutic to treat cancers and sensitize them to established therapies.
Selected Publications
Qian Y*, Basu R*, Mathes SC, Arnett NA, Duran-Ortiz S, Funk KR, Brittain AL, Kulkarni P, Terry JC, Davis E, Singerman JT, Henry BE, List EO, Berryman DE, Kopchick JJ. Cancers (Basel). 2020 Growth Hormone Upregulates Mediators of Melanoma Drug Efflux and Epithelial-to-Mesenchymal Transition In Vitro and In Vivo. Dec 4;12(12):3640. doi: 10.3390/cancers12123640. PMID: 33291663
Young J, Bell S, Qian Y, Hyman C, Berryman DE. Rev Endocr Metab Disord. 2020 Mouse models of growth hormone insensitivity. Oct 10. doi: 10.1007/s11154-020-09600-6. Online ahead of print. PMID: 33037595
Basu R, Kulkarni P, Qian Y, Walsh C, Arora P, Davis E, Duran-Ortiz S, Funk K, Ibarra D, Kruse C, Mathes S, McHugh T, Brittain A, Berryman DE, List EO, Okada S, Kopchick JJ. (2019) Growth Hormone Upregulates Melanocyte-Inducing Transcription Factor Expression and Activity via JAK2-STAT5 and SRC Signaling in GH Receptor-Positive Human Melanoma. Cancers (Basel). Sep 12;11 (9). PMID: 31547367.
List EO, Berryman DE, Buchman M, Jensen EA, Funk KR, Duran-Ortiz Silvana, Qian Y, Young JA, Slyby J, McKenna S, Kopchick JJ. (2019) GH “knockout” mice have increased subcutaneous adipose tissue with decreased fibrosis and enhanced insulin sensitivity. Endocrinology. 2019 Jul 1;160 (7):1743-1756. PMID: 31099824.
Qian Y*, Basu R*, and Kopchick JJ. (2018) Lessons from the growth hormone receptor gene-disrupted mice: are there benefits of endocrine defects? European Journal of Endocrinology. 178:R155-R181. PMID: 29459441.
Brittain AL, Basu R, Qian Y, and Kopchick JJ. (2017) Growth hormone and the Epithelial-to-Mesenchymal Transition. J. Clin. Endocrinol. Metab, 102(10):3662-3673. doi: 10.1210/jc.2017-01000. PMID: 28938477.
Qian Y, Wang X, Li Y, Cao Y, Chen X. (2016) Extracellular ATP a new player in cancer metabolism: NSCLC cells internalize ATP in vitro and in vivo using multiple endocytotic mechanisms. Mol. Cancer Res. 14(11):1087-1096. PMID: 27578770.
Chen X, Qian Y, Wu S. (2015) The Warburg effect: evolving interpretations of an established concept. Free. Radic. Biol. Med. 79:253-63. PMID: 25277420.
Qian Y, Wang X, Liu Y, Li Y, Colvin R, Tong L, Wu S, and Chen X. (2014) Extracellular ATP is internalized by macropinocytosis and induces intracellular ATP increase and drug resistance in cancer cells. Cancer Lett. 351(2): 242-51. PMID: 24973521.
Qian Y, Wang X, and Chen X. (2014) Inhibitors of glucose transport and glucose metabolism as novel anticancer therapeutics. World J. Transl. Med. 3(2): 37-57. doi: http://dx.doi.org/10.5528/wjtm.v3.i2.37
Chen FX, Qian YR, Duan YH, Ren WW, Yang Y, Zhang CC, Qiu YM, and Ji YH. (2009) Down-regulation of 67LR reduces the migratory activity of human glioma cells in vitro. Brain Res Bull. 79(6):402-8. PMID: 19446013.