Douglas Goetz

Journal Article, Academic Journal (58)

• McCall, K., Walter, D., Patton, A., Thuma, J., Courreges de Benencia, M., Palczewski, G., Goetz, D., Bergmeier, S., Schwartz, F. (2023). Anti-Inflammatory and Therapeutic Effects of a Novel Small-Molecule Inhibitor of Inflammation in a Male C57BL/6J Mouse Model of Obesity-Induced NAFLD/MAFLD. 16 . Journal of Inflammation Research; 2023: 5339-5366.
• Ghazanfari, D., Courreges de Benencia, M., Belinski, L., Lloyd, J., Bergmeier, S., McCall, K., Goetz, D. (2022). Mechanistic Insights into SARS-CoV-2 Spike Protein Induction of the Chemokine CXCL10. Submitted.
• Ghazanfari, D., Courreges, M., Belinski, L., Bergmeier, S., McCall, K., Goetz, D. (2022). Evidence for investigating GSK-3 inhibitors as potential therapeutics for severe COVID-19. Biochemical and Biophysical Research Communications; 605: 171-176.
• Ghazanfari, D., Noori, M., Bergmeier, S., Hines, J., McCall, K., Goetz, D. (2021). A novel GSK-3 inhibitor binds to GSK-3β via a reversible, time and Cys-199-dependent mechanism.. Bioorganic & medicinal chemistry; 40: 116179.
• Kauffman, M., Allen, A., Reynolds, N., Ghazanfari, D., Nazemidashtarjandi, S., Faik, A., Burdick, M., McCall, K., Goetz, D. (2020). Evidence that Knock Down of GSK-3b in Haploid Chronic Myelogenous Leukemia Cells Augments IFN-g Induced Apoptosis and Necrosis. Leukemia Research.
• Kauffman, M., Nazemidashtarjandi, S., Ghazanfari, D., Allen, A., Reynolds, N., Faik, A., Burdick, M., McCall, K., Goetz, D. (2020). Evidence that knock down of GSK-3β in Chronic Myelogenous Leukemia cells augments IFN-γ-induced apoptosis.. Leukemia Research; 99: 106464.
• Noori, M., Courreges, M., Bergmeier, S., McCall, K., Goetz, D. (2020). Modulation of LPS-induced inflammatory cytokine production by a novel glycogen synthase kinase-3 inhibitor.. European Journal of Pharmacology; 883: 173340.
• Noori, M., Bodle, S., Showalter, C., Streator, E., Drozek, D., Burdick, M., Goetz, D. (2020). Sticking to the Problem: Engineering Adhesion in Molecular Endoscopic Imaging.. 2 . Cellular and molecular bioengineering; 13: 113-124.
• Noori, M., Bhatt, P., Courreges, M., Ghazanfari, D., Cuckler, C., Orac, C., McMills, M., Schwartz, F., Deosarkar, S., Bergmeier, S., McCall, K., Goetz, D. (2019). Identification of a novel selective and potent inhibitor of glycogen synthase kinase-3. Am J Physiol - Cell Physiol; 317: C1289-C1303.
• Martin, E., Malgor, R., Resto, V., Goetz, D., Burdick, M. (2019). Dynamic biochemical tissue analysis detects functional selectin ligands on cancer tissues. 1 . 9: 8511. http://www.nature.com/articles/s41598-019-44838-4 .
• Noori, M., Streator, E., Carlson, G., Drozek, D., Burdick, M., Goetz, D. (2018). An adhesion based approach for the detection of esophageal cancer.. 12 . Integrative Biology; 10: 747-757.
• Patton, A., Church, T., Wilson, C., Thuma, J., Goetz, D., Berryman, D., List, E., Schwartz, F., McCall, K. (2018). Phenylmethimazole abrogates diet-induced inflammation, glucose intolerance and NAFLD.. 3 . The Journal of endocrinology; 237: 337-351.
• Noori, M., O'Brien, J., Champa, Z., Deosarkar, S., Lanier, O., Qi, C., Burdick, M., Schwartz, F., Bergmeier, S., McCall, K., Goetz, D. (2017). Phenylmethimazole and a Thiazole Derivative of Phenylmethimazole Inhibit IL-6 Expression by Triple Negative Breast Cancer Cells. European Journal of Pharmacology; 803: 130-137. http://www.sciencedirect.com/science/article/pii/S0014299917302182?via%3Dihub .
• Carlson, G., Martin, E., Shirure, V., Malgor, R., Resto, V., Goetz, D., Burdick, M. (2017). Dynamic biochemical tissue analysis detects functional L-selectin ligands on colon cancer tissues. 3 . PLoS ONE; 12: e0173747. https://doi.org/10.1371/journal.pone.0173747 .
• Alapati, A., Deosarkar, S., Lanier, O., Qi, C., Carlson, G., Burdick, M., Schwartz, F., McCall, K., Bergmeier, S., Goetz, D. (2015). Simple Modifications to Methimazole that Enhance its Inhibitory Effect on Tumor Necrosis Factor-alpha-Induced Vascular Cell Adhesion Molecule-1 Expression by Human Endothelial Cells. European Journal of Pharmacology; 751: 59-66.
• Alapati, A., Deosarkar, S., Lanier, O., Qi, C., Carlson, G., Burdick, M., Schwartz, F., McCall, K., Bergmeier, S., Goetz, D. (2015). Simple modifications to methimazole that enhance its inhibitory effect on tumor necrosis factor-α-induced vascular cell adhesion molecule-1 expression by human endothelial cells.. European journal of pharmacology; 751: 59-66.
• Shirure, V., Liu, T., Delgadillo, L., Cuckler, C., Tees, D., Benencia, F., Goetz, D., Burdick, M. (2015). CD44 variant isoforms expressed by breast cancer cells are functional E-selectin ligands under flow conditions. 1 . American Journal of Physiology-Cell Physiology; 308: C68-78.
• Malgor, R., Bhatt, P., Connelly, B., Jacoby, D., Feldman, K., Silver, M., Nakazawa, M., McCall, K., Goetz, D. (2014). Wnt5a, TLR2 and TLR4 are Elevated in Advanced Human Atherosclerotic Lesions. Inflammation Research; 63: 277-285.
• Deosarkar, S., Bhatt, P., Gillespie, J., Goetz, D., McCall, K. (2014). Inhibition of LPS-induced TLR4 signaling products in murine macrophages by phenylmethimazole: an assay methodology for screening potential phenylmethimazole analogs.. 8 . Drug development research; 75: 497-509.
• Malgor, R., Bhatt, P., Connolly, B., Jacoby, D., Feldmann, K., Silver, M., Nakazawa, M., McCall, K., Goetz, D. (2014). Wnt5a, TLR2 and TLR4 are elevated in advanced human atherosclerotic lesions.. 4 . Inflammation research : official journal of the European Histamine Research Society ... [et al.]; 63: 277-85.
• Courreges, M., Kantake, N., Goetz, D., Schwartz, F., McCall, K. (2012). Phenylmethimazole blocks dsRNA-induced IRF3 nuclear translocation and homodimerization.. 10 . Molecules (Basel, Switzerland); 17: 12365-77.
• Burdick, M., Henson, K., Delgadillo, L., Choi, Y., Goetz, D., Tees, D., Benencia, F. (2012). Expression of E-selectin ligands on circulating tumor cells: Cross-regulation with cancer stem cell regulatory pathways?. Frontiers In Oncology; 2: 103 (11 pages).
• Kummitha, C., Shirure, V., Delgadillo, L., Deosarkar, S., Tees, D., Burdick, M., Goetz, D. (2012). HECA-452 is a Non-Function Blocking Antibody for Sialyl Lewis-x Microsphere Adhesion to Endothelial Expressed E-selectin Under Flow Conditions. 1-2 . Journal of Immunological Methods; 384: 43-50.
• Bhatt, P., Lewis, C., House, D., Keller, C., Kohn, L., Silver, M., McCall, K., Goetz, D., Malgor, R. (2012). Increased Wnt5a mRNA Expression in Advanced Atherosclerotic Lesions, and Oxidized LDL Treated Human Monocyte-Derived Macrophages.. The open circulation & vascular journal; 5: 1-7.
• Deosarkar, S., Bhatt, P., Lewis, C., Goetz, D. (2011). Detection of Inflamed Endothelial Cells in Whole Blood Using Quantitative Real-Time PCR: A Potential Diagnostic/Prognostic Assay for Atherosclerosis.. 10 . Annals of Biomedical Engineering; 39: 2627-2636.
• Bhatt, P., Lewis, C., House, D., Goetz, D., Malgor, R. (2011). Oxidized LDL increases Wnt5a mRNA expression in human monocyte-derived macrophages.
• Narayanaswamy, N., Faik, A., Goetz, D., Gu, T. (2011). Supercritical Carbon Dioxide Pretreatment of Corn Stover and Switchgrass for Lignocellulosic Ethanol Production. Bioresource Technology; 102: 6995-7000. https://www.sciencedirect.com/science/article/pii/S0960852411005669?via%3Dihub .
• Kummitha, C., Mayle, K., Christman, M., Deosarkar, S., Schwartz, A., McCall, K., Kohn, L., Malgor, R., Goetz, D. (2010). A sandwich ELISA for the Detection of Wnt5a. 1-2 . Journal of Immunological Methods; 352: 38-44.
• Benavides, U., Gonzalez-Murguiondo, M., Harii, N., Lewis, C., Sakhalkar, H., Deosarkar, S., Kurjiaka, D., Dagia, N., Goetz, D., Kohn, L. (2010). Phenyl methimazole suppresses dextran sulfate sodium-induced murine colitis. 1 . European Journal of Pharmacology; 643: 129-138.
• Kummitha, C., Mayle, K., Christman, 2nd, M., Deosarkar, S., Schwartz, A., McCall, K., Kohn, L., Malgor, R., Goetz, D. (2010). A sandwich ELISA for the detection of Wnt5a.. 1-2 . Journal of immunological methods; 352: 38-44.
• Schwartz, A., Malgor, R., Dickerson, E., Weeraratna, A., Slominski, A., Wortsman, J., Harii, N., Kohn, A., Moon, R., Schwartz, F., Goetz, D., Kohn, L., McCall, K. (2009). Phenylmethimazole decreases Toll-like receptor 3 and noncanonical Wnt5a expression in pancreatic cancer and melanoma together with tumor cell growth and migration.. 12 . Clinical cancer research : an official journal of the American Association for Cancer Research; 15: 4114-22.
• Sundd, P., Zou, X., Goetz, D., Tees, D. (2008). Leukocyte Adhesion in Capillary-Sized, P-selectin Coated Micropipettes. 2 . Microcir.; 15: 109-22.
• Deosarkar, S., Malgor, R., Fu, J., Kohn, L., Hanes, J., Goetz, D. (2008). Polymeric Particles Conjugated with a Ligand to VCAM-1 Exhibit Selective, Avid and Focal Adhesion to Sites of Atherosclerosis. 2 . Biotech. and Bioeng.; 101: 400-7.
• Christman, 2nd, M., Goetz, D., Dickerson, E., McCall, K., Lewis, C., Benencia, F., Silver, M., Kohn, L., Malgor, R. (2008). Wnt5a is expressed in murine and human atherosclerotic lesions.. 6 . American journal of physiology. Heart and circulatory physiology; 294: H2864-70.
• Hamm, A., Goetz, D., Klibanov, A., Lawrence, M. (2007). Microparticle Adhesive Dynamics and Rolling Mediated by Selectin Specific Antibodies under Flow. 3 . Biotech. and Bioeng.; 96: 596-607.
• Sakhalkar, H., Hanes, J., Fu, J., Benavides, U., Malgor, R., Borruso, C., Kohn, L., Kurjiaka, D., Goetz, D. (2005). Enhanced Adhesion of Ligand-Conjugated Biodegradable Particles to Colitic Venules. FASEB J.; 19: 792-794.
• Zou, X., Shinde Patil, V., Dagia, N., Smith, L., Wargo, M., Interliggi, K., Lloyd, C., Tees, D., Walcheck, B., Lawrence, M., Goetz, D. (2005). PSGL-1 Derived from Human Neutrophils is a High Efficiency Ligand for Endothelial Expressed E-selectin under Flow. Am. J. Phys. – Cell Phys.; 289: C415-424.
• Yuan, H., Goetz, D., Gaber, M., Issekutz, A., Merchant, T., Kiani, M. (2005). Radiation-Induced Up-regulation of Adhesion Molecules in Brain Microvasculature and their Modulation by Dexamethasone. Radiat Res.; 163: 544-51.
• Harii, N., Lewis, C., Vasko, V., McCall, K., Benavides-Peralta, U., Ringel, M., Saji, M., Giuliani, C., Napolitano, G., Goetz, D., Kohn, L. (2005). Thyrocytes Express a Functional Toll-like receptor 3 (TLR3): Overexpression Can Be Induced by Viral Infection, Reversed by Pheylmethimazole, and Is Associated with Hashimoto’s Autoimmune Thyroiditis. Mol. Endo.; 19: 1231-1250.
• Kohn, L., Schwartz, F., Silver, M., Goetz, D. (2005). Toll-like Receptors in Nonimmune Cells and Environmental Induction of the Pathologic Expression of Innate Immunity and Autoimmune Inflammatory Diseases: A New Therapeutic Opportunity. Spring; 3-11.
• Yun, Y., Goetz, D., Yellen, P., Chen, W. (2004). Hyaluronan Microspheres for Sustained Gene Delivery and Site Specific Targeting. Biomaterials; 25: 147-157.
• Dagia, N., Harii, N., Meli, A., Sun, X., Lewis, C., Kohn, L., Goetz, D. (2004). Phenyl Methimazole Inhibits TNF-α-Induced VCAM-1 Expression in an IFN Regulatory Factor-1-Dependent Manner and Reduces Monocytic Cell Adhesion to Endothelial Cells. J. Immunol.; 173: 2041-2049.
• Dagia, N., Goetz, D. (2003). A Proteasome Inhibitor Reduces Concurrent, Sequential and Long-term IL-1 and TNF-α-induced ECAM Expression and Adhesion. Am J. Physiol.; 285: C813-C822.
• Tees, D., Goetz, D. (2003). Leukocyte Adhesion: An Exquisite Balance of Hydrodynamic and Molecular Forces. News in Physiological Sciences; 18: 186-190.
• Kiani, M., Yuan, H., Chen, X., Smith, L., Gaber, M., Goetz, D. (2002). Targeting Microparticles to Select Tissues via Radiation-Induced Upregulation of Endothelial Cell Adhesion Molecules. Pharm. Res.; 19: 1317-1322.
• Burch, E., Shinde Patil, V., Camphausen, R., Kiani, M., Goetz, D. (2002). The N-terminal Peptide of PSGL-1 Can Mediate Adhesion to Trauma-Activated Endothelium via P-selectin in Vivo. Blood; 100: 531-538.
• Prabhakarpandian, B., Goetz, D., Swerlick, R., Chen, X., Kiani, M. (2001). Expression and Functional Significance of Adhesion Molecules on Cultured Endothelial Cells in Response to Ionizing Radiation. 5 . Microcirc.; 8: 355-364.
• Blackwell, J., Dagia, N., Dickerson, J., Berg, E., Goetz, D. (2001). Ligand Coated Nanosphere Adhesion to E- and P-selectin under Static and Flow Conditions. 6 . Annals of Biomedical Engineering; 29: 523-533.
• Dickerson, J., Blackwell, J., Ou, J., Shinde Patil, V., Goetz, D. (2001). Limited Adhesion of Biodegradable Microspheres to E- and P-selectin under Flow. Biotechnology and Bioengineering; 73: 500-509.
• Shinde Patil, V., Campbell, C., Yuan, Y., Slack, S., Goetz, D. (2001). Particle Diameter Influences Adhesion Under Flow. Biophys J.; 80: 1733-1743.
• Crutchfield, K., Shinde Patil, V., Campbell, C., Parkos, C., Allport, J., Goetz, D. (2000). CD11b/CD18-coated microspheres attach to E-selectin under Flow. J. Leuk. Biol.; 67: 196-205.
• Lim, Y., Wakelin, M., Henault, L., Goetz, D., Yednock, T., Cabanas, C., Sanchez-Madrid, F., Lichtman, A., Luscinskas, F. (2000). 41 Integrin Activation is Necessary for High Efficiency T Cell Subset Interactions with VCAM-1 under Flow. Microcirc.; 7: 201-214.
• Goetz, D., Greif, D., Ding, H., Camphausen, R., Howes, S., Comess, K., Snapp, K., Kansas, G., Luscinskas, F. (1997). Isolated P-selectin Glycoprotein Ligand-1 Dynamic Adhesion to P- and E-selectin. J. Cell Biol.; 137: 509-519.
• Goetz, D., Ding, H., Atkinson, W., Vachino, G., Camphausen, R., Cumming, D., Luscinskas, F. (1996). A Human Colon Carcinoma Cell Line Exhibits Adhesive Interactions with P-selectin under Fluid Flow via a PSGL-1 Independent Mechanism. Am. J. Path; 149: 1661-1673.
• Goetz, D., Brandley, B., Hammer, D. (1996). An E-selectin-IgG Chimera Supports Sialylated Moiety Dependent Adhesion of Human Carcinoma Cells under Fluid Flow. Annals of Biomed. Eng.; 24: 87-98.
• Goetz, D., El-Sabban, M., Hammer, D., Pauli, B. (1996). Lu-ECAM-1 Mediated Adhesion of Melanoma Cells to Endothelium under Conditions of Flow. Int. J. Cancer; 65: 192-199.
• Brunk, D., Goetz, D., Hammer, D. (1996). Sialyl-Lewisx/E-selectin-Mediated Rolling in a Cell-Free System. Biophys. J.; 71: 2902-2908.
• Goetz, D., El-Sabban, M., Pauli, B., Hammer, D. (1994). Dynamics of Neutrophil Rolling Over Stimulated Endothelium in Vitro. Biophys. J.; 66: 2202-2209.

Patent (15)

• Goetz, D., Begmeier, S., McMills, M., Orac, C. Imidazole and thiazole compositions for modifying biological signaling . 10,633,377.
• Goetz, D., Bergmeier, S., McMills, M., Orac, C. Imidazole and thiazole compositions for modifying biological signaling -B. 10,407,420.
• McCall, K., Schwartz, F., Goetz, D. Prevention and treatment of non-alcoholic fatty liver disease (new compounds). 10,392,381.
• Goetz, D., Bergmeier, S., McMills, M., Orac, C. Imidazole and thiazole compositions for modifying biological signaling - C . Application # 20200017489.
• McMills, M., Goetz, D., Bergmeier, S., Orac, C. Imidazole and Thiazole Compositions for Modifying Biological Signaling . 10,023,567.
• McCall, K., Schwartz, F., Goetz, D., Malgor, R. Prevention and treatment of non-alcoholic fatty liver disease . 9,750,723.
• Kohn, L., Harri, N., Benavides-Peralta, U., Gonzalez-Murguiondo, M., Lewis, C., Goetz, D., Napolitano, G., Giuliani, C., Malgor, R., Schwartz, F., McCall, K. Use of phenylmethimazoles, methimazole derivatives, and tautomeric cyclic thiones for the treatment of autoimmune/inflammatory diseases associated with toll-like receptor overexpression. 9,326,972.
• Kohn, L., Harri, N., Benavides-Peralta, U., Gonzalez-Murguiondo, M., Lewis, C., Goetz, D., Napolitano, G., Giuliani, C., Malgor, R., Schwartz, F., McCall, K. Use of phenylmethimazoles, methimazole derivatives, and tautomeric cyclic thiones for the treatment of autoimmune/inflammatory diseases associated with toll-like receptor overexpression (Broadens 9,326972).
• Goetz, D., McCall, K., Bergmeier, S., Schwartz, F., Bhatt, P., Deosarkar, S. Methods and compositions to modify GSK-3 activity.
• Bergmeier, S., Goetz, D., McMall, K. A method to modify the activity of GSK-3.
• Bergmeier, S., Goetz, D., McMall, K. Use of phenylmethyimazole for the prevention and treatment of fatty liver disease.
• Bergmeier, S., Goetz, D., McMills, M., McMall, K. Compositions that modify biological signaling.
• Burdick, M., Goetz, D., Malgor, R., Shirure, V., Resto, V. Dynamic biochemical tissue analysis. WO/2013/006405 .
• Kohn, L., Goetz, D., Benavides-Peralta, U., Gonzalez-Murguiondo, M., Harii, N., Lewis, C., Napolitano, G., Dagia, N. Methods for the Amelioration of Episodes of Acute and Chronic Ulcerative Colitis. 7,928,132.
• Goetz, D., Kiani, M. Targeting drug/gene carriers to irradiated tissue. 7,182,933.

Book, Chapter in Scholarly Book (3)

• Tees, D., Sundd, P., Goetz, D. (2006). "A Flow Chamber for Capillary Networks: Leukocyte Adhesion in Capillary-Sized Ligand-Coated Micropipettes" in Principles of Cellular Engineering: Understanding the Biomolecular Interface . New York: M.R. King; 213-231.
• Goetz, D., Greif, D., Shen, J., Luscinskas, F. (1999). "Cell-Cell Adhesive Interactions in an In Vitro Flow Chamber" in Adhesion Protein Protocols . Humana Press; 137-145.
• Hammer, D., Tempelman, L., Goetz, D. (1994). "Kinetics and Mechanics of Cell Adhesion under Hydrodynamic Flow: Two Cell Systems" in Cellular Mechanics and Cellular Engineering . New York: Springer-Verlag Inc.; 121-144.

Conference Proceeding (6)

• Bhatt, P., Lewis, C., House, D., Goetz, D., Malgor, R. (2010). Upregulation of Wnt5a transcripts in human monocytes treated with ox-LDL. Conference abstracts for the 2010 Biomedical Engineering Society Annual Meeting.
• Malgor, R., Lewis, C., Keller, C., Kohn, L., Silver, M., Goetz, D. (2010). Wnt5a expression in human atherosclerotic plaques is elevated in macrophage-rich and complicated plaques. 2 . ATHEROSCLEROSIS SUPPLEMENTS; 11: 135-135.
• Tees, D., Sundd, P., Choi, Y., Goetz, D., Pai, A., Rogers, S. (2010). Neutrophil motion, adhesion and activation in an in vitro micropipette model of a lung capillary. Proceedings of the 3rd Joint US-European Fluids Engineering Summer Meeting and 8th International Conference on Nanochannels, Microchannels and Minichannels, August 1-5, 2010, Montreal, Canada: American Society of Mechanical Engineers; FEDSM-ICNMM2010-30177: 1-11.
• Sakhalkar, H., Dalal, M., Salem, A., Ansari, R., Fu, J., Kiani, M., Kurjiaka, D., Hanes, J., Shakesheff, K., Goetz, D. (2003). Leukocyte-Inspired Biodegradable Particles that Selectively and Avidly Adhere to Inflamed Endothelium In Vitro and In Vivo. Proceedings of the National Academy of Sciences; 100: 15985-15900.
• Young, V., Ridgway, D., Prudich, M., Goetz, D., Stuart, B. (2001). Criterion-Based Grading for Learing and Assessment in Unit Operations Laboratory. Albuquerque, NM: 2001 ASEE Annual Conference.
• Young, V., Ridgway, D., Prudich, M., Goetz, D., Stuart, B. (2001). Criterion-Based Grading for Learning and Assessment in Unit Operations Laboratory. Albuquerque, NM: Session 3213, American Society for Engineering Education 2001 National Meeting.