BEGIN:VCALENDAR
VERSION:2.0
CALSCALE:GREGORIAN
PRODID:iCalendar-Ruby
BEGIN:VEVENT
CATEGORIES:Lectures & Presentations
DESCRIPTION:Chemistry Colloquium: Dr. Darren Reid\n\nDr. Darren L. Reid wil
l be the guest speaker for the Nov. 13th Chemistry & Biochemistry Colloquiu
m:Staging InnovaIve Drug Candidates for Success - Molecule Assessment. Dr.
Reid is Director of Process Development\, Drug Product Technologies at Amge
n.\n\n \n\nAbstract:\n\nTherapeutic drug strategies are rapidly evolving in
the postgenomic era\, expanding the druggable target space. In this new er
a\, a transition is occurring in drug discovery towards novel approaches to
bind and modulate challenging biological targets that have led to transfor
mative treatments for patients. In the small molecule space\, drugging nove
l targets using a variety of molecular modalities and strategies\, such as
PROTACs (protein-targeted chimeras)\, pro-drugs\, and covalent binders\, ha
ve become a key focus in drug discovery. The challenges these strategies pr
esent for drug development will be discussed\, including how molecule asses
sment and form selection are used to help achieve suitable bioavailability\
, stability (chemical/physical) and manufacturability\, making delivery to
patients possible. Data science (Atlas Synthetics)\, modeling (Zeneth)\, an
d automation tools being used and developed to support these efforts at Amge
n will be reviewed. A case study will be shared describing how molecule ass
essment and form selection supported the accelerated development of LUMAKRA
S™(sotosasib)\, the first treatment for patients with KRAS G12C-mutated loca
lly advanced or metastaLc non-small cell lung cancer.
DTEND:20241113T220500Z
DTSTAMP:20241114T043938Z
DTSTART:20241113T211000Z
GEO:39.322732;-82.10287
LOCATION:Walter Hall\, Room 145
SEQUENCE:0
SUMMARY:Chemistry Colloquium: Dr. Darren Reid
UID:tag:localist.com\,2008:EventInstance_47931605302493
URL:https://calendar.ohio.edu/event/chemistry-colloquium-dr-darren-reid
END:VEVENT
END:VCALENDAR