BEGIN:VCALENDAR VERSION:2.0 CALSCALE:GREGORIAN PRODID:iCalendar-Ruby BEGIN:VEVENT CATEGORIES:Lectures & Presentations DESCRIPTION:Chemistry Colloquium: Dr. Darren Reid\n\nDr. Darren L. Reid wil l be the guest speaker for the Nov. 13th Chemistry & Biochemistry Colloquiu m:Staging InnovaIve Drug Candidates for Success - Molecule Assessment. Dr. Reid is Director of Process Development\, Drug Product Technologies at Amge n.\n\n \n\nAbstract:\n\nTherapeutic drug strategies are rapidly evolving in the postgenomic era\, expanding the druggable target space. In this new er a\, a transition is occurring in drug discovery towards novel approaches to bind and modulate challenging biological targets that have led to transfor mative treatments for patients. In the small molecule space\, drugging nove l targets using a variety of molecular modalities and strategies\, such as PROTACs (protein-targeted chimeras)\, pro-drugs\, and covalent binders\, ha ve become a key focus in drug discovery. The challenges these strategies pr esent for drug development will be discussed\, including how molecule asses sment and form selection are used to help achieve suitable bioavailability\ , stability (chemical/physical) and manufacturability\, making delivery to patients possible. Data science (Atlas Synthetics)\, modeling (Zeneth)\, an d automation tools being used and developed to support these efforts at Amge n will be reviewed. A case study will be shared describing how molecule ass essment and form selection supported the accelerated development of LUMAKRA S™(sotosasib)\, the first treatment for patients with KRAS G12C-mutated loca lly advanced or metastaLc non-small cell lung cancer. DTEND:20241113T220500Z DTSTAMP:20241122T134332Z DTSTART:20241113T211000Z GEO:39.322732;-82.10287 LOCATION:Walter Hall\, Room 145 SEQUENCE:0 SUMMARY:Chemistry Colloquium: Dr. Darren Reid UID:tag:localist.com\,2008:EventInstance_47931605302493 URL:https://calendar.ohio.edu/event/chemistry-colloquium-dr-darren-reid END:VEVENT END:VCALENDAR