BEGIN:VCALENDAR VERSION:2.0 CALSCALE:GREGORIAN PRODID:iCalendar-Ruby BEGIN:VEVENT CATEGORIES:Lectures & Presentations DESCRIPTION:The Oct. 30th Chemistry & Biochemistry Collquium guest speaker will be Prof. Hao Shen: Creation and Development of the Electron Spin Catal yst Dr. Shen is an Assistant Professor in the Chemistry & Biochemistry depa rtment at Kent State University.\n\n \n\nWe have introduced a novel form of electron spin catalyst termed coronazymes\, which consist of an achiral go ld nanoparticle (AuNP) core encased by a surrounding DNA strand. It exhibit s exceptional catalytic reactivity and selectivity compared to traditional nanozymes due to the strong binding affinity of the DNA\, which also facili tates long-range catalysis on DNA bases instead of the AuNP surfaces. Throu gh the utilization of single-molecule fluorescence spectroscopy and a fluor ogenic reaction\, we conducted a comprehensive investigation into the react ion kinetics and mechanism of coronazyme. Our findings reveal that a cataly tic turnover initiates a charge transfer chain at the AuNP-DNA interface\, followed by subsequent charge transfers within the DNA strand and release o f charges to the reaction substrate. This charge injection at the interface is governed by chirality-induced spin selectivity (CISS)\, making the over all reactivity of coronazyme dependent on electron spin. The spin polarizat ion at the interface can be enhanced by an external magnetic field or circu larly polarized light (CPL)\, resulting in CPL-dependent reactivity. Exciti ng the DNA with CPL that matches its handedness leads to twice the reactivi ty compared to CPL with mismatched handedness. The chiral DNA hairpin enhan ces spin polarization as the electrons transfer through the DNA\, and this capability is influenced by the conformation of the DNA. By applying extern al forces to alter the DNA conformation\, we effectively modify the efficac y of spin filtering and subsequently control the reactivity of coronazyme. Additionally\, we have invented novel instrumentation and developed innovat ive analytical methodologies for the creation of coronazymes. DTEND:20241030T210500Z DTSTAMP:20241122T195845Z DTSTART:20241030T201000Z GEO:39.322732;-82.10287 LOCATION:Walter Hall\, 135 SEQUENCE:0 SUMMARY:Chemistry Colloquium: Prof. Hao Shen UID:tag:localist.com\,2008:EventInstance_47846255144558 URL:https://calendar.ohio.edu/event/chemistry-colloquium-prof-hao-shen END:VEVENT END:VCALENDAR