BEGIN:VCALENDAR VERSION:2.0 CALSCALE:GREGORIAN PRODID:iCalendar-Ruby BEGIN:VEVENT CATEGORIES:Lectures & Presentations DESCRIPTION:Chemistry Colloquium: Dr. Xiaohong Tan\, March 6\n\nDr. Xiaohon g Tan will be the guest speaker for the Department of Chemistry & Biochemis try Colloquium on March 6th "Prepare for SARS-CoV-3. Dr. Tan is an Assistan t Professor in the Department of Chemistry and Center for Photochemical Sci ences at Bowling Green State University.\n\n \n\nThe potential emergence of SARS-CoV-3 in the future signifies the arrival of a new Beta-coronavirus f ollowing SARS-CoV-1 and SARS-CoV-2. Over the past two decades\, three Beta- coronaviruses have led to severe pandemics: SARS-CoV-1\, MERS-CoV\, and SAR S-CoV-2. Beta-coronaviruses employ their viral spike proteins on the surfac e to interact with human cell receptors. Notably\, the SARS-CoV-2 spike pro tein consists of two subunits\, S1 and S2. The S2 subunit exhibits remarkab le conservation across the entire coronavirus family. For instance\, the S2 domains of both SARS-CoV-1 and SARS-CoV-2 share a high degree of similarit y\, with approximately 93.1% conserved residues. Given these scientific fin dings\, it is reasonable to expect that the hypothetical SARS-CoV-3 will al so feature a highly conserved S2 domain. Consequently\, the substantial str uctural and sequence conservation of S2 holds great promise for the develop ment of universal cross-reactive therapeutics and vaccines. During this pre sentation\, I will introduce universal DNA aptamers designed to target cons erved domains\, such as S2\, in the spike proteins of SARS-CoV-2. Our resea rch has demonstrated that these aptamers can universally recognize the spik e proteins of SARS-CoV-1 as well. We believe that these aptamer tools can b e a valuable resource in preparation for the potential emergence of SARS-Co V-3 in the future. DTEND:20240306T220500Z DTSTAMP:20241005T102830Z DTSTART:20240306T211000Z GEO:39.322732;-82.10287 LOCATION:Walter Hall\, 145 SEQUENCE:0 SUMMARY:Chemistry Colloquium: Dr. Xiaohong Tan\, March 6 UID:tag:localist.com\,2008:EventInstance_45348426151694 URL:https://calendar.ohio.edu/event/chemistry_colloquium_dr_xiaohong_tan END:VEVENT END:VCALENDAR