BEGIN:VCALENDAR VERSION:2.0 CALSCALE:GREGORIAN PRODID:iCalendar-Ruby BEGIN:VEVENT CATEGORIES:Lectures & Presentations DESCRIPTION:Chemistry Seminar | Alumna\, Honorary Degree Recipient Jue Chen \, April 29 \n\nOhio University alumna Jue Chen will present a Chemistry & Biochemistry seminar\, discussing “CFTR\, the Odd ABC Transporter Responsib le for Cystic Fibrosis.” on Friday\, April 29\, from 4:10 to 5:05 p.m. in W alter 245.\n\n \n\nChen\, named an Ohio University Honorary Degree recipien t in 2020\, will be on campus to receive that degree at the graduate commen cement on April 29.\n\n \n\nChen earned a B.S. in Chemistry through the Hon ors Tutorial College in 1993. Her Ph.D. was earned in 1998 at Harvard Unive rsity under the direction of the late Don C. Wiley.\n\n \n\nShe is currentl y the William E. Ford Professor at the Rockefeller University and an invest igator with the Howard Hughes Medical Institute. \n\n \n\nShe was named a m ember of the National Academy of Sciences in 2019.\n\n \n\nAbstract: The wo rk in my lab is centered on ATP-binding cassette (ABC) transporters. These are a diverse group of membrane proteins utilizing the chemical energy of ATP hydrolysis to transport substrates against their electrochemical gradie nts. Among the thousands of ABC transporters\, one member\, the cystic fib rosis transmembrane conductance regulator (CFTR)\, has evolved to function as an ATP-gated ion channel. Mutation of the CFTR gene causes cystic fibro sis (CF)\, a lethal disease with a prevalence of 1 in 2500 in Caucasian pop ulations. In this talk\, I will present the structures of CFTR\, describe its unique features that enable a mechanistic understanding of why this par ticular ABC transporter functions as an ion channel\, how the channel activ ity is regulated\, and how the drugs interact and modulate CFTR. DTEND:20220429T210500Z DTSTAMP:20240921T043753Z DTSTART:20220429T201000Z GEO:39.322732;-82.10287 LOCATION:Walter Hall\, 245 SEQUENCE:0 SUMMARY:Chemistry Seminar | Alumna\, Honorary Degree Recipient Jue Chen\, A pril 29 UID:tag:localist.com\,2008:EventInstance_39633318125529 URL:https://calendar.ohio.edu/event/chemistry_seminar_alumna_honorary_degre e_recipient_jue_chen_april_29 END:VEVENT END:VCALENDAR