BEGIN:VCALENDAR VERSION:2.0 CALSCALE:GREGORIAN PRODID:iCalendar-Ruby BEGIN:VEVENT CATEGORIES:Lectures & Presentations DESCRIPTION:Molecular and Cellular Biology Seminar | Samantha Hunter\, Oct. 17\n\nThe Molecular and Cellular Biology Seminar series (MCB7410) features Samantha Hunter discussing "The Rise of the Hollow Fiber Infection Model " on Oct. 17 at 3:30 PM in Porter Hall Room 104.\n\n \n\nHunter is with the Ohio University Biological Sciences Department\, Molecular and Cellular Bio logy Program.\n\n \n\nAbstract: Antimicrobial resistance is becoming one of the largest concerns in healthcare. Last line of defense medications are n o longer working. There is a fear that resistant microbial populations coul d grow out of control and obstruct currently effective treatment of infecti ous disease. Understanding the interactions between the host system\, the m icrobe\, and the medications are imperative for improving treatments for re sistant species. With the hollow fiber infection model (HFIM)\, it’s possib le to do just that. Designed in the 1980s\, it provides an area for the mic robes to grow\, be exposed to antimicrobials\, and be sampled all without c ompromising the integrity of the system. The HFIM has been used for studyin g antimicrobial resistance in bacteria and finding the lowest effect doses of medications for treatment of HIV. The use of this model allows researche rs to test medications against microbes in a manner that mimics the in vivo environment of the host by creating a closed loop that minimizes outside i nterference. This model works well as a standalone model or together with a nimal models. As seen in the research done by Garimella et al.\, 2019\, the HFIM can be used to test multiple medications and obtain the pharmacokinet ics and pharmacodynamics using those drugs in combination. Hope et al.\, 20 19 uses this model to demonstrate the ineffectiveness of current guidelines for the antifungal medication fluconazole for treatment of cryptococcal me ningitis. Overall\, this in vitro model has been an incredible advancement in studying the emergence of resistance and reviewing current guidelines of medication dosing of microbes. \n\nGarimella N\, Zere T\, Hartman N\, Gan dhi A\, Bekele A\, Li X\, Stone H\, Sacks L\, Weaver JL. Effect of drug com binations on the kinetics of antibiotic resistance emergence in Escherichia coli CFT073 using an in vitro hollow-fibre infection model. Int J Antimicr ob Agents. 2020 Apr\;55(4):105861. doi: 10.1016/j.ijantimicag.2019.105861. Epub 2019 Dec 13. PMID: 31838036. \n\nHope W\, Stone NRH\, Johnson A\, McEn tee L\, Farrington N\, Santoro-Castelazo A\, Liu X\, Lucaci A\, Hughes M\, Oliver JD\, Giamberardino C\, Mfinanga S\, Harrison TS\, Perfect JR\, Bican ic T. Fluconazole Monotherapy Is a Suboptimal Option for Initial Treatment of Cryptococcal Meningitis Because of Emergence of Resistance. mBio. 2019 D ec 3\;10(6):e02575-19. doi: 10.1128/mBio.02575-19. PMID: 31796539\; PMCID: PMC6890991. DTEND:20231017T203000Z DTSTAMP:20241123T033728Z DTSTART:20231017T193000Z GEO:39.324787;-82.103474 LOCATION:Porter Hall\, 104 SEQUENCE:0 SUMMARY:Molecular and Cellular Biology Seminar | Samantha Hunter\, Oct. 17 UID:tag:localist.com\,2008:EventInstance_44404808129266 URL:https://calendar.ohio.edu/event/molecular_and_cellular_biology_seminar_ samantha_hunter_oct_10 END:VEVENT END:VCALENDAR