BEGIN:VCALENDAR VERSION:2.0 CALSCALE:GREGORIAN PRODID:iCalendar-Ruby BEGIN:VEVENT CATEGORIES:Lectures & Presentations DESCRIPTION:Physics Colloquium | Energy-Information Prescription for Synaps es\, March 12\n\nThe Physics & Astronomy Colloquium Series presents alumnus Suhita Nadkarni of Indian Institute of Science Education and Research (IIS ER)\, Pune\, India on “Energy-Information Prescription for Synapses” on Fri day\, March 12\, at 4:10 p.m. at an Online Departmental Colloquium.\n\nAbst ract: Synapses are hotspots for learning and memory and can be extremely co mplex. They possess diverse morphologies\, receptor types\, ion channels\, and second messengers. The differences between synaptic designs across brai n areas suggest a link between synaptic form and function. Additionally\, s everal brain disorders have a synaptic basis. However\, direct measurements at a synapse are often difficult. Motivated by the synapses' vital role in brain function and the experimental constraints that may pose a barrier to a complete understanding of brain function\, we construct ‘in silico' mode ls of synapses with unprecedented detail. This modeling framework lets us a ddress fundamental questions about information processing at synapses and m ake quantitative predictions.\n\nThe human brain makes up about 2% of the b odyweight but uses about 25% of the body's total energy budget. Within that \, signal transmission at synapses alone is an energetically expensive proc ess and consumes more than 50% of the brain's total energy. If every electr ical impulse generated in the brain is transmitted to the connected synapse s\, the brain will need at least five times more energy than it already con sumes. The CA3-CA1 synapse in the hippocampus is a crucial component of the neural circuit associated with learning. This synapse has a curiously low fidelity — Only 1 in 5 impulses are transmitted. The low transmission rate suggests a synaptic design that lowers energy consumption is favored. Howev er\, unreliable transmission can lead to a massive loss of information. We used information transmission and energy utilization\, fundamental constrai nts that govern the neural organization\, to gain insights into the relatio nship between form and function of this synapse. We show that unreliable ne urotransmitter release and its activity-dependent enhancement (short-term p lasticity)\, a characterizing attribute of this synapse\, maximizes informa tion transmitted in an energetically cost-effective manner. Remarkably\, ou r analysis reveals that synapse-specific quirks ensure information rate is independent of the release probability. Thus\, even as ongoing long-term me mory storage continues to fuel heterogeneity in synaptic strengths\, indivi dual synapses maintain robust information transmission. DTEND:20210312T221000Z DTSTAMP:20241123T195118Z DTSTART:20210312T211000Z LOCATION: SEQUENCE:0 SUMMARY:Physics Colloquium | Energy-Information Prescription for Synapses\, March 12 UID:tag:localist.com\,2008:EventInstance_35714725084155 URL:https://calendar.ohio.edu/event/physics_colloquium_biotechnology_march_ 12 END:VEVENT END:VCALENDAR