Chair, Biomedical Sciences; Professor of Bacteriology
Life Sciences Building 235, Athens Campus
Biomedical Engineering
Education:
- Microbiology (PhD), State University of New York at Buffalo, 2002
- Biology (BS), State University of New York at Geneseo, 1997
Expertise:
- Bacteriology
- Infectious Disease
- Gene Regulation
- RNA Thermometer (RNAT)
- Shigella
- Staphylococcus aureus
- Microbiology
- Small RNA (sRNA)
Summary of Work:
Our research focuses on understanding how disease-causing bacteria regulate gene expression in response to specific environmental conditions encountered within the infected host. Focus is placed on the study of RNA-mediated gene regulation that impact the ability of bacteria to survive within the host and cause disease.
Links:
View My Work in Open Researcher and Contributor ID (ORCID)
https://orcid.org/0000-0002-5716-4829
View My Work in the National Center for Biotechnology Information (NCBI)
https://www.ncbi.nlm.nih.gov/myncbi/1tCJrmvSX3S5F/bibliography/public/
Journal Article, Academic Journal (17)
- Sarpong, D., Murphy, E. (2021). RNA Regulated Toxin-Antitoxin Systems in Pathogenic Bacteria. Frontiers in Cellular and Infection Microbiology.
- Bastock, R., Marino, E., Wiemels, R., Holzschu, D., Keogh, R., Zapf, R., Murphy, E., Carroll, R. (2021). Staphylococcus aureus Responds to Physiologically Relevant Temperature Changes by Altering Its Global Transcript and Protein Profile.. 2 . mSphere; 6.
- Jensen, E., Young, J., Jackson, Z., Busken, J., List, E., Carroll, R., Kopchick, J., Murphy, E., Berryman, D. (2020). Growth Hormone Deficiency and Excess Alter the Gut Microbiome in Adult Male Mice.. 4 . Endocrinology; 161.
- Murphy, E., Roßmanith, J., Sieg, J., Fris, M., Hussein, H., Kouse, A., Gross, K., Zeng, C., Hines, J., Narberhaus, F., Coschigano, P. (2020). Regulation of OmpA Translation and Shigella dysenteriae Virulence by an RNA Thermometer.. 3 . Infection and immunity; 88.
- Jensen, E., Young, J., Mathes, S., List, E., Carroll, R., Kuhn, J., Onusko, M., Kopchick, J., Murphy, E., Berryman, D. (2020). Crosstalk between the growth hormone/insulin-like growth factor-1 axis and the gut microbiome: A new frontier for microbial endocrinology.. Growth hormone & IGF research : official journal of the Growth Hormone Research Society and the International IGF Research Society; 53-54: 101333.
- Jensen, E., Berryman, D., Murphy, E., Carroll, R., Busken, J., List, E., Broach, W. (2019). Heterogeneity spacers in 16S rDNA primers improve analysis of mouse gut microbiomes via greater nucleotide diversity.. 2 . BioTechniques; 67: 55-62.
- Hussein, H., Fris, M., Salem, A., Wiemels, R., Bastock, R., Righetti, F., Burke, C., Narberhaus, F., Carroll, R., Hassan, N., Mohamed, S., Fahmy, A., Murphy, E. (2019). An unconventional RNA-based thermosensor within the 5' UTR of Staphylococcus aureus cidA.. 4 . PloS one; 14: e0214521.
- Wei, Y., Kouse, A., Murphy, E. (2017). Transcriptional and posttranscriptional regulation of Shigella shuT in response to host-associated iron availability and temperature.. 3 . MicrobiologyOpen; 6.
- Fris, M., Broach, W., Klim, S., Coschigano, P., Carroll, R., Caswell, C., Murphy, E. (2017). Sibling sRNA RyfA1 Influences Shigella dysenteriae Pathogenesis.. 2 . Genes; 8.
- Wei, Y., Murphy, E. (2016). Shigella Iron Acquisition Systems and their Regulation.. Frontiers in cellular and infection microbiology; 6: 18.
- Fris, M., Murphy, E. (2016). Riboregulators: Fine-Tuning Virulence in Shigella.. Frontiers in cellular and infection microbiology; 6: 2.
- Caswell, C., Oglesby-Sherrouse, A., Murphy, E. (2014). Sibling rivalry: related bacterial small RNAs and their redundant and non-redundant roles.. Frontiers in cellular and infection microbiology; 4: 151.
- Kouse, A., Righetti, F., Kortmann, J., Narberhaus, F., Murphy, E. (2013). RNA-mediated thermoregulation of iron-acquisition genes in Shigella dysenteriae and pathogenic Escherichia coli.. 5 . PloS one; 8: e63781.
- Oglesby-Sherrouse, A., Murphy, E. (2013). Iron-responsive bacterial small RNAs: variations on a theme.. 4 . Metallomics : integrated biometal science; 5: 276-86.
- Murphy, E., Broach, W., Kouse, A. (2012). Prokaryotic Gene Regulation by Small RNAs.
- Broach, W., Egan, N., Wing, H., Payne, S., Murphy, E. (2012). VirF-independent regulation of Shigella virB transcription is mediated by the small RNA RyhB.. 6 . PloS one; 7: e38592.
- Africa, L., Murphy, E., Egan, N., Wigley, A., Wing, H. (2011). The iron-responsive Fur/RyhB regulatory cascade modulates the Shigella outer membrane protease IcsP.. 11 . Infection and immunity; 79: 4543-9.
Book, Chapter in Scholarly Book (1)
- Murphy, E., Broach, W., Kouse, A. (2014). Prokaryotic Gene Regulation by Small RNAs .
Abstract (1)
- Jensen, J., Jackson, J., Busken, J., Young, J., Kuhn, J., Carroll, R., List, E., Murphy, E., Kopchick, J., Berryman, D. (2019). Growth Hormone (GH) Impacts the Gut Microbial Profile: the Presence of Unique Bacterial Genera in Mouse Lines with Altered GH Action. 1 . 3.